Adaptive meets innate: CD8+ T cells kill MHC-I-negative tumour cells
BWA Peeters, GM Gillespie - Nature Reviews Immunology, 2023 - nature.com
BWA Peeters, GM Gillespie
Nature Reviews Immunology, 2023•nature.comReservoirs of allergic memory Page 1 nature reviewsimmunology Volume 23 | May 2023 |
269–272 | 272 Preprint watch Reservoirs of allergic memory Allergic disease is driven by
plasma cells that produce allergen-specific Ige, which binds to high-affinity receptors on mast
cells and basophils and causes their degranulation after allergen cross-linking. Allergies can be
lifelong, but Ige-producing plasma cells are short-lived and Ige+ memory B cells (MBCs) are very
rare. The current consensus is that allergen-specific B cell memory is maintained by non-Ige …
269–272 | 272 Preprint watch Reservoirs of allergic memory Allergic disease is driven by
plasma cells that produce allergen-specific Ige, which binds to high-affinity receptors on mast
cells and basophils and causes their degranulation after allergen cross-linking. Allergies can be
lifelong, but Ige-producing plasma cells are short-lived and Ige+ memory B cells (MBCs) are very
rare. The current consensus is that allergen-specific B cell memory is maintained by non-Ige …
A preprint by Lerner et al. shows that conventional CD8+ T cells can kill tumour cells lacking MHC class I expression in an NKG2D-dependent manner.
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